Microscope

Publications

Selected References

Zhang L, Jackson CB, Mou H, Ojha A, Peng H, Quinlan B, Rangarajan E, Pan A, Vanderheiden A, Suthar M, Li W,  Izard T, Rader C, Farzan M, Choe H.  SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity. Nature Commun.

https://rdcu.be/cbIST

Jackson CB, Zhang L, Farzan M, Choe H. Functional importance of the D614G mutation in the SARS-CoV-2 spike protein. Biochem Biophys Res Commun., in press. Review.

https://doi.org/10.1016/j.bbrc.2020.11.026


Jackson CB, Richard AS, Ojha A, Conkright KA, Trimarchi JM, Bailey CC, Alpert MD, Kay MA, Farzan M, Choe H.  AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery.  Mol Ther Methods Clin Dev., in press

https://doi.org/10.1016/j.omtm.2020.11.004


Zhang L, Richard AS, Jackson CB, Ojha A, Choe H.   Phosphotidylethanolamine and phosphatidylserine synergize to enhance GAS6/AXL-mediated virus infection and efferocytosis.   J. Virol., in press.

https://doi.org/10.1128/JVI.02079-20


Brell J, Berg V, Modak M, Puck A, Zlabinger G, Steinberger P, Chou J, Geha R, Öhler L, Yachie A, Choe H, Stöckl J.  Transferrin receptor 1 is a cellular receptor for human heme-albumin. Nature Commun.

https://doi.org/10.1038/s42003-020-01294-5


Laczko  D, Hogan MJ, Toulmin SA, Hicks P, Lederer K, Gaudette BT, Castano D, Amanat F, Muramatsu H, Oguin III TH, Ojha A, Zhang L, Mu Z, Parks R, Manzoni TB, Roper B, Strohmeier S, Tombacz I, Arwood L, Nachbagauer R, Kariko K, Greenhouse Pessaint JL, Porto M, Putman-Taylor T, Strasbaugh A, Campbell T, Lin PJC, Tam YK, Sempowski GD, Farzan M, Choe H, Saunders KO, Haynes BF, Andersen H, Eisenlohr LC, Weissman D, Krammer F, Bates P, Allman D, Locci M, Pardi N.  A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.  Immunity 2020 Oct 13;53(4):724-732.

https://doi.org/10.1016/j.immuni.2020.07.019


Shim BS, Kwon YC, Ricciardi MJ, Stone M, Otsuka Y, Berri F, Kwal JM, Magnani DM, Jackson CB, Richard AS, Norris P, Busch M, Curry CL, Farzan M, Watkins D, Choe H.  Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice.  mBio. 2019 Jul 2;10(4). pii: e00758-19. (PMCID: PMC6606798)

https://doi.org/10.1128/mBio.00758-19


Reed AJ, Connelly RP, Williams A, Tran M, Shim BS, Choe H, Gerasimova YV.  Label-Free Pathogen Detection by a Deoxyribozyme Cascade with Visual Signal Readout.  Sens Actuators B Chem. 2019 Mar 1;282:945-951. (PMCID: PMC6713451)

https://doi.org/10.1016/j.snb.2018.11.147


Otsuka Y, Schmitt K, Quinlan BD, Gardner MR, Alfant B, Reich A, Farzan M, Choe H.  Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies.  PLoS Pathog. 2018 Aug 20;14(8):e1007238. (PMCID: PMC6117093)

https://doi.org/10.1371/journal.ppat.1007238


Ricciardi MJ, Magnani DM, Grifoni A, Kwon YC, Gutman MJ, Grubaugh ND, Gangavarapu K, Sharkey M, Silveira CGT, Bailey VK, Pedreño-Lopez N, Gonzalez-Nieto L, Maxwell HS, Domingues A, Martins MA, Pham J, Weiskopf D, Altman J, Kallas EG, Andersen KG, Stevenson M, Lichtenberger P, Choe H, Whitehead SS, Sette A, Watkins DI.  Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL.  PLoS Negl Trop Dis. 2017 Dec 21;11(12):e0006000. (PMCID: PMC29267278)

https://doi.org/10.1371/journal.pntd.0006000


Richard AS, Shim BS, Kwon YC, Zhang R, Otsuka Y, Schmitt K, Berri F, Diamond MS, Choe H. AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses. Proc Natl Acad Sci U S A. 2017 Feb 21; 114(8): 2024-9. (PMCID: PMC28167751)

https://doi.org/10.1073/pnas.1620558114


Thenin-Houssier S, de Vera IM, Pedro-Rosa L, Brady A, Richard A, Konnick B, Opp S, Buffone C, Fuhrmann J, Kota S, Billack B, Pietka-Ottlik M, Tellinghuisen T, Choe H, Spicer T, Scampavia L, Diaz-Griffero F, Kojetin DJ, Valente ST.  Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.  Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. (PMCID: PMC4808204)

https://doi.org/10.1128/AAC.02574-15


Huang WC, Abraham R, Shim BS, Choe H*, Page DT*.  Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice.  Sci Rep. 2016 Oct 7;6:34793. (PMCID: PMC5054421) *co-corresponding authors

https://doi.org/ 10.1038/srep34793


Richard AS, Zhang A, Park S, Farzan M, Zong M, Choe H.  Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue and West Nile viruses.  Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47): 14682–7. (PMCID: PMC4664333)

https://doi.org/10.1073/pnas.1508095112


Rathbun JY, Droniou ME, Damoiseaux R, Haworth KG, Henley JE, Exline CM, Choe H, Cannon PM.  Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.  J Virol. 2015 Aug 15;89(16):8428-43. (PMCID: PMC4524252)

https://doi.org/10.1128/JVI.00997-15


Zong M, Fofana I, Choe H.  Human and host species transferrin receptor 1 use by North American arenaviruses.  J Virol. 2014 Aug;88(16):9418-28. (PMCID: PMC4136298) 

https://doi.org/10.1128/JVI.01112-14


Demogines A, Abraham J, Choe H, Farzan M, Sawyer SL.  Dual host-virus arms races shape an essential housekeeping protein. PLoS Biol. 2013;11(5):e1001571. (PMCID: PMC3665890)

https://doi.org/10.1371/journal.pbio.1001571


Jemielity J, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, DeKruyff RJ, Choe H.  TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLos Pathog. 2013 Mar 28;9(3):e1003232. (PMCID: PMC3610696)

https://doi.org/10.1371/journal.ppat.1003232


Helguera G, Jemielity S, Abraham J, Cordo SM, Martinez MG, Rodríguez JA, Bregni C, Wang JJ, Farzan M, Penichet ML, Candurra NA, Choe H.  An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all New World hemorrhagic fever arenaviruses.  J Virol. 2012 Apr;86(7):4024-8. (PMCID: PMC3302512)

https://doi.org/10.1128/JVI.06397-11


Kwong JA, Dorfman T, Quinlan BD, Chiang JJ, Ahmed AA, Choe H, Farzan M. A Tyrosine-Sulfated CCR5-Mimetic Peptide Promotes Conformational Transitions in the HIV-1 Envelope Glycoprotein. J Virol. 2011 Aug;85(15):7563-71. (PMCID: PMC365685) 

https://doi.org/10.1128/JVI.00630-11


Choe H, Jemielity S, Abraham J, Radoshitzky SR, Farzan M. Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses.  Curr Opin Microbiol. 2011 Aug;14(4):476-82. Review. (PMCID: PMC3159852)   

https://doi.org/10.1016/j.mib.2011.07.014


Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011 Jan 6;7(1):e1001258. (PMCID: PMC2346733)   

https://doi.org/10.1371/journal.ppat.1001258


Abraham J, Corbett KD, Farzan M, Choe H, Harrison SC.  Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr;17(4):438-44. (PMCID: PMC2920743)  

https://doi.org/10.1038/nsmb.1772


Choe H, Farzan M.  Chapter 7. Tyrosine sulfation of HIV-1 coreceptors and other chemokine receptors.  Methods Enzymol.  2009; 461:147-70.

https://doi.org/10.1016/S0076-6879(09)05407-X


Abraham J, Kwong JA, Albariño CG, Lu JG, Radoshitzky SR, Salazar-Bravo J, Farzan M, Spiropoulou CF, Choe H.  Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic New World clade B arenaviruses.  PLoS Pathog. 2009 Apr;5(4):e1000358.  (PMCID: PMC2658809)

https://doi.org/10.1371/journal.ppat.1000358


Radoshitzky SR, Kuhn JH, Spiropoulou CF, Albariño CG, Nguyen DP, Salazar-Bravo J, Dorfman T, Lee AS, Wang E, Ross SR, Choe H, Farzan M.  Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses.  Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2664-9. (PMCID: PMC2268193)

https://doi.org/10.1073/pnas.0709254105


Liu CC, Mack AV, Tsao ML, Mills JH, Lee HS, Choe H, Farzan M, Schultz PG, Smider VV. Protein evolution with an expanded genetic code. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17688-93. (PMCID: PMC2584696)   

https://doi.org/10.1073/pnas.0809543105


Radoshitzky SR, Abraham J, Spiropoulou CF, Kuhn JH, Nguyen D, Li W, Nagel J, Schmidt PJ, Nunberg JH, Andrews NC, Farzan M, Choe H.  Transferrin receptor 1 is a cellular receptor for New World hemorrhagic fever arenaviruses.  Nature 2007, Mar 1;446(7131):92-6.  (PMCID: PMC2658809)

https://doi.org/10.1038/nature05539


Choe H, Farzan M.  Tyrosine sulfate trapped by amber.  Nat Biotechnol. 2006 Nov;24(11):1361-2.

https://www.nature.com/articles/nbt1106-1361


Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PM, Choe H.  SARS Coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.  J Biol Chem.  2006 Feb;281(6):3198-3203.  (PMCID: PMC1142572)

https://doi.org/10.1074/jbc.M508381200

Li W, Greenough TC, Moore M, Vasilieva N, Somasundaran M, Sullivan JL, Farzan M, Choe H.   Efficient replication of SARS coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.  J Virol.  2004 Oct;78(20):11429-33. (PMCID: PMC521845)

https://doi.org/10.1128/JVI.78.20.11429-11433.2004



Moore M, Dorfman T, Li W, Wong SK, Coderre J, Vasilieva N, Greenough TC, Farzan M, Choe H.   Retroviruses pseudotyped with the Severe Acute Respiratory Syndrome coronavirus spike protein efficiently infect cells expressing Angiotensin-Converting Enzyme 2.  J Virol.  2004 Oct;78(19):10628-35. (PMCID: PMC516384)

https://doi.org/10.1128/JVI.78.19.10628-10635.2004


Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD.  Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.  Proc Natl Acad Sci U S A.  2004 Mar;101(9):2706-11. (PMCID: PMC365685)

https://doi.org/10.1073/pnas.0308527100


Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H*, Farzan M*.  Angiotensin-converting Enzyme 2 is a Functional Receptor for the SARS coronavirus.  Nature.  2003 Nov;426(6965): 450-4. *co-corresponding authors

https://doi.org/10.1038/nature02145


Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson JE, Sodroski JG, Farzan M. Tyrosine Sulfation of Human Antibodies Contributes to Recognition of the CCR5 Binding Region of HIV-1 gp120.  Cell.  2003 Jul;114(2): 161-70.

https://doi.org/10.1016/S0092-8674(03)00508-7


Farzan M, Babcock GJ, Vasilieva N, Wright PL, Kiprilov E, Mirzabekov T, Choe H.  The role of post-translational modifications of the CXCR4 amino-terminus in SDF-1 association and HIV-1 entry.  J Biol Chem.  2002 Aug;277(33): 29484-9.

https://doi.org/10.1074/jbc.M203361200


Farzan M, Chung S, Li W, Vasilieva N, Schnitzler CE, Marchione RJ, Gerard C, Gerard NP, Sodroski J, Choe H.  Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region.  J Biol Chem.  2002 Oct;277(43):40397-402.

https://doi.org/10.1074/jbc.M206784200


Farzan M, Schnitzler CE, Vasilieva N, Leung D, Kuhn J, Gerard C, Gerard NP, Choe H.   Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor.  J Exp Med.  2001 May;193(9):1059-66.

https://doi.org/10.1084/jem.193.9.1059


2000 and earlier
Farzan M, Mirzakov T, Kolchinsky P, Wyatt R, Cayabyab M, Gerard NP, Gerard C, Sodroski J, Choe H.  Tyrosine Sulfation of Amino Terminus of CCR5 facilitates HIV-1 Entry.  Cell.  1999 Mar;96(5):667-76.

https://doi.org/10.1016/S0092-8674(00)80577-2


Choe H.  Chemokine receptors in HIV-1 and SIV infection.  Arch Pharm Res.  1998 Dec;21(6):634-9. Review.

https://doi.org/10.1007/BF02976749


Choe H, Farzan M, Konkel M, Marcon L, Cayabyab M, Gerard NP, Gerard C and Sodroski J.  The Orphan seven-transmembrane segment receptor apj supports the entry of primary dual- and T-tropic HIV-1 Isolates.  J Virol.  1998 Jul;72(7):6113-8. (PMCID: PMC110417)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110417/


He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D.  CCR3 andCCR5 are co-receptors for HIV-1 infection of microglia.  Nature.  1997 Feb;385(6617):645-9.

https://doi.org/10.1038/385645a0


Farzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N, Gerard NP, Gerard C, Sodroski J.  Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.  J Exp Med.  1997 Aug;186(3):405-11. (PMCID: PMC2198994)

https://doi.org/10.1084/jem.186.3.405


Wu L, Gerard NP, Wyatt R, Choe H, Parolin C, Ruffing N, Borsetti A, Cardoso AA, Desjardin E, Newman W, Gerard C, Sodroski J.  CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR5.  Nature. 1996 Nov;384(6605):179-83.

https://doi.org/10.1038/384179a0


Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA.  The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.  Nature.  1996 Aug;382(6594):829-33.

https://doi.org/10.1038/382829a0


Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard NP, Gerard C, Sodroski J.  The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.  Cell.  1996 Jun;85(7):1135-48.

https://doi.org/10.1016/S0092-8674(00)81313-6